Ithebhulethi yeNicolsamide
I-Niclosamide iyi-salicylanilide ene-chlorine etholakala ngomlomo nge-bioavailable, ene-anthelmintic kanye nomsebenzi ongaba khona we-antineoplastic.Lapho iphathwa ngomlomo, i-niclosamide idala ngokukhethekile ukuwohloka kwe-androgen receptor (AR) okuhlukile kwe-V7 (AR-V7) ngokusebenzisa indlela ye-proteasome-mediated.Lokhu kwehlisa ukuvezwa kokuhlukile kwe-AR, kuvimbela umsebenzi wokulotshwa kwe-AR-V7-mediated, futhi kunciphisa ukubuthwa kwe-AR-V7 kumthuthukisi wofuzo we-prostate-specific antigen (PSA).I-Niclosamide iphinde ivimbele i-AR-V7-mediated STAT3 phosphorylation nokwenza kusebenze.Lokhu kuvimbela ukusayinda okuphakathi kwe-AR/STAT3 futhi kuvimbela ukuvezwa kofuzo oluqondiwe lwe-STAT3.Sekukonke, lokhu kungase kuvimbele ukukhula kwamaseli omdlavuza we-AR-V7-overexpressing.Okuhlukile kwe-AR-V7, okubhalwe ngekhodi ukuhlukaniswa okuhlangene kwe-AR exons 1/2/3/CE3, kulawulwa ngezinhlobo zamangqamuzana omdlavuza, futhi kuhlotshaniswa nakho kokubili ukuqhubeka komdlavuza kanye nokumelana nemithi yokwelapha eqondiswe yi-AR.
Ukwakhiwa:
I-bolus ngayinye ine-1250 mg ye-niclosamide
Inkomba:
Okwezilwane ezifuywayo ezinegciwane i-paramphistomes, i-cestodiasis, njengezinkomo nezimvu ze-moniezia, i-avitellina centripunctata, njll.
Umthamo kanye nokusetshenziswa:
Ngomlomo ngamunye 1kg isisindo somzimba.
Izinkomo: 40-60mg
Izimvu: 60-70mg
Isikhathi sokuhoxa:
Izimvu: izinsuku ezingama-28.
Izinkomo: izinsuku ezingu-28.
Usayizi wephakheji: amaphilisi ama-5 ngebhamuza ngalinye, amabhamuza ayi-10 ibhokisi ngalinye
